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Redesigning Gene-Editing Proteins with AlphaFold to Reduce Off-Target Effects

Vidgetc VidgetcAuthor
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Gene-editing therapies face safety challenges because even highly specific DNA-targeting systems can occasionally edit the wrong sequences, especially when treating many cells. To address this, researchers used AlphaFold to identify parts of gene-editing proteins linked to off-target activity.

They then modified those regions to reduce unintended edits. The work was published in Nature.

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