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Researchers Use AlphaFold AI to Redesign Gene-Editing Proteins, Reducing Off-Target Risks

Vidgetc VidgetcAuthor
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Gene-editing therapies face safety challenges due to off-target effects, where the editing machinery accidentally modifies unintended DNA sequences. To address this, scientists adapted the AI protein-folding program AlphaFold to pinpoint regions in gene-editing proteins responsible for these errors. By modifying those specific areas, they successfully reduced the likelihood of off-target edits, improving the safety profile of gene-editing tools.

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